来稿:陈琳  北京康复中心神经外科

Brain Res. 2013 Aug  12.

 

Transplantation of autologous bone marrow mesenchymal  stem cells in the treatment of complete and chronic cervical spinal cord  injury

 

Xu  R.

 

Neuronal injuries have been a challenging problem for  treatment, especially in the case of complete and chronic cervical spinal cord  injury (SCI). Recently, particular attention is paid to the potential of stem  cell in treating SCI, but there are only few clinical studies and insufficient  data. This study explored the efficacy of autologous bone marrow mesenchymal  stem cells (BMMSCs) transplantation in the treatment of SCI. Forty patients with  complete and chronic cervical SCI were selected and randomly assigned to one of  the two experimental groups, treatment group and control group. The treatment  group received BMMSCs transplantation to the area surrounding injury, while the  control group was not treated with any cell transplantation. Both the transplant  recipients and the control group were followed up to 6 months, postoperatively.  Preoperative and postoperative neurological functions were evaluated with AIS  grading, ASIA score, residual urine volume and neurophysiological  examination. Results showed that in the treatment group 10 patients had a  significant clinical improvement in terms of motor, light touch, pin prick  sensory and residual urine volume, while nine patients showed changes in AIS  grade. Neurophysiological examination was consistent with clinical observations.  No sign of tumor was evident until 6 months postoperatively. In the control  group, no improvement was observed in any of the neurological functions  specified above. BMMSCs transplantation improves neurological function in  patients with complete and chronic cervical SCI, providing valuable information  on applications of BMMSCs for the treatment of SCI. KEYWORDS: Bone marrow  mesenchymal stem cells, Spinal cord injury, Stem cell  transplantation


196例晚期脊髓损伤患者人类神经干细胞移植:I/II
脊髓损伤患者自体骨髓间充质干细胞移植临床研究报告

Previous:

Next:

自体骨髓间充质干细胞移植治疗晚期完全性颈脊髓损伤