• 来稿:陈琳   北京市虹天济神经科学研究院

  • J Neurotrauma.  2007 Jun;24(6):1026-36

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  • Neuroprotective effect of bone  marrow-derived mononuclear cells promoting functional recovery from spinal cord  injury

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  • Yoshihara T, Ohta M, Itokazu Y,  Matsumoto N, Dezawa M, Suzuki Y, Taguchi A,

  • Watanabe Y, Adachi Y, Ikehara S,  Sugimoto H, Ide C.

  • Department of Anatomy and Neurobiology,  Kyoto University Graduate School of Medicine, Kyoto, Japan. t-yoshihara@umin.ac.jp

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  • Neural cell transplantation, a new therapeutic strategy  for replacing injured neural components and obtaining functional recovery, has  shown beneficial effects in animal models. Use of this strategy in human  patients, however, requires that a number of serious issues be addressed,  including ethics, immunorejection, and the therapeutic time window within which  the procedure will be effective. Bone marrow-derived mononuclear cells (BM-MNC)  are attractive for transplantation because they can be used as an autograft, can  be easily collected within a short time period, and do not have to be cultured.  In a rat model of spinal cord injury (SCI), we transplanted BM-MNC at 1 h after  SCI at Th 8-9 by injecting them into the cerebrospinal fluid (CSF), and  investigated the effect of this on neurologic function. In the acute stage of  injury, we found a neuroprotective antiapoptotic effect, with an elevated  concentration of hepatocyte growth factor in CSF. At 1 week after  transplantation, the Basso-Beattie-Bresnahan locomotor score had increased  significantly over its base-line value. In the chronic stage of injury, we  observed suppressed cavity formation and functional improvement. We conclude  that transplantation of BM-MNC after SCI has a remarkable neuroprotective effect  in the acute stage of injury, suppressing cavity formation, and contributing to  functional recovery. Our results suggest that transplantation of BM-MNC via the  CSF is a potentially effective means of enhancing functional recovery after SCI  in humans.

 

 

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锂盐远期疗法现有数据的系统评价:神经保护抑或神经毒害?
系统评估肌萎缩性侧索硬化临床试验中的神经保护因子

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骨髓源性单核细胞促进脊髓损伤功能恢复的神经保护作用