• 来稿:陈琳   北京市虹天济神经科学研究院

  • Curr Pharm Des. 2005;11(10):1211-22.  Review.

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  • Neuroprotection and regeneration  strategies for spinal cord repair

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  • Tsai EC, Tator  CH.

  • The Canadian Paraplegic Association  Spinal Cord Injury Research Laboratory, Krembil Neuroscience Center, Toronto  Western Hospital and University of Toronto, Toronto, Ontario,  Canada.

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  • The journey toward a cure for spinal  cord injury (SCI) has taken many paths. In this article, we review these paths,  and highlight the clinical applications of these experimental repair strategies.  Initial strategies involved attempts at neuroprotection with steroids and other  anti-inflammatory drugs. Other anti-ischemia treatments, agents to eliminate the  damage from excitotoxicity, and anti-apoptotic agents were also tried. Another  avenue involved enhancing the function of the remaining uninjured axons by  measures to produce remyelination and medications to improve axonal conduction.  In the last two decades there has been a major effort to enhance spinal cord  axonal regeneration through a variety of techniques including neutralization of  neurite inhibition, administration of neurotrophic factors, implantation of  synthetic channels, and transplantation of a variety of cell types. Indeed,  several of these strategies have been so promising in animals that clinicians  have been stimulated to explore their potential human application. We also  examine the different experimental models of SCI used to assess repair, and  discuss how the injury model impacts on the assessment of axonal regeneration  and functional recovery after SCI. The mechanisms of recovery that may be  involved after SCI will be analyzed, and their relevance toward finding a cure  for human SCI. Unfortunately, the goal of producing significant functional  regeneration of the human spinal cord has not yet been achieved despite the many  strategies that have been developed. It is our hope that improved understanding  of the mechanisms underlying functional recovery will lead to successful  therapeutic strategies in humans.


神经外科中的炎症反应
中枢神经系统再生的概念与策略

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脊髓损伤的神经保护与神经再生策略