• 来稿:陈琳   北京市虹天济神经科学研究院

  • Best Pract Res Clin Anaesthesiol. 2004  Sep;18(3):407-24.   

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  • Inflammatory response after  neurosurgery

  • Mutlu LK, Woiciechowsky C, Bechmann  I.

  • Department of Cell and Neurobiology,  Institute of Anatomy, Humboldt University Medical School-Charité,  Berlin, Germany.

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  • Investigation into the inflammatory  response in the central nervous system (CNS) is a rapidly growing field, and a  vast amount of information on this topic has accumulated over the past two  decades. Inflammation is a particularly interesting issue in the (traditionally  non-regenerating) CNS, owing to its dual role in worsening or improving  regeneration and functional outcome in certain circumstances. This paper reviews  the current literature on the interactions between the immune system and the CNS  in physiological and pathological states. The first part will provide an  overview of the cellular and molecular components of CNS inflammation, this  being followed by a discussion of the concept of systemic immunodepression after  neurotrauma and neurosurgery. Finally, the delicate balance of immune responses  in the CNS, with an emphasis on the beneficial effects of inflammation and  possible therapeutic options, will be discussed.


顽固性癫痫的局部治疗
脊髓损伤的神经保护与神经再生策略

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