• 来稿:陈琳   北京市虹天济神经科学研究院

  • Bull Soc Sci Med  Grand Duche Luxemb. 2008;(2):217-57. 

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  • Brain repair how stem cells are changing  neurology

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  • Modo  M.

  • Centre for the Cellular Basis of Behaviour,  Kings College London,  Institute of Psychiatry, London, UK. mike.modo@iop.kcl.ac.uk

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  • The concept that everything can die, but nothing can  regenerate in the brain has been replaced with new hope that stem cells will  provide avenues to repair the damaged central nervous system (CNS). The  treatment of brain damage has been demonstrated preclinically using a variety of  stem cell sources. The prototypical cell that gives rise to the CNS is the  neural stem cell (NSC). NSCs differentiate into site-appropriate phenotypes when  transplanted into the damage brain and can recover lost functions. In some  cases, cells can be pre-differentiated into a particular neuronal phenotype,  such as dopaminergic cells, that can then be transplanted ectopically to promote  behavioural improvements in conditions like Parkinson's disease. Early clinical  studies in PD have demonstrated the proof of principle that this approach can  improve neurodegenerative disease. The current review will discuss the different  sources of stem cells in their preclinical and clinical application, as well as  providing an overview as to the issues that need to be addressed to ensure a  successful translation from bench to bedside.

 

 


有价值的学术争论——尝试骑上各种“马”
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