• 来稿:陈琳   北京市虹天济神经科学研究院

  •  Adv Exp Med Biol.  2007;595:197-212.

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  • Neuroprotective effects of  curcumin

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  • Cole GM, Teter B, Frautschy  SA

  •  Greater  Los Angeles Veterans Affairs Healthcare System,  Geriatric Research, Education, and Clinic Center, Sepulveda, CA  91343, USA. gmcole@ucla.edu

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  • Neurodegenerative diseases result in the loss of  functional neurons and synapses. Although future stem cell therapies offer some  hope, current treatments for most of these diseases are less than adequate and  ourbest hope is to prevent these devastating diseases. Neuroprotective  approaches work best prior to the initiation of damage, suggesting that some  safe and effective prophylaxis would be highly desirable. Curcumin has an  outstanding safety profile and a number of pleiotropic actions with potential  for neuroprotective efficacy, including anti-inflammatory, antioxidant, and  anti-protein-aggregate activities. These can be achieved at submicromolar  levels. Curcumin's dose-response curves are strongly dose dependent and often  biphasic so that in vitro data need to be cautiously interpreted; many effects  might not be achievable in target tissues in vivo with oral dosing. However,  despite concerns about poor oral bioavailability, curcumin has at least 10 known  neuroprotective actions and many of these might be realized in vivo. Indeed,  accumulating cell culture and animal model data show that dietary curcumin is a  strong candidate for use in the prevention or treatment of major disabling  age-related neurodegenerative diseases like Alzheimer's, Parkinson's, and  stroke. Promising results have already led to ongoing pilot clinical  trials.

 


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