• 来稿:陈琳   北京市虹天济神经科学研究院

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  • Mol Neurobiol. 2007  Jun;35(3):217-23.

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  • Exercise-induced neuroprotection in SMA  model mice: a means for determining new therapeutic  strategies

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  • Charbonnier  F

    Laboratoire  de Neurobiologie des Réseaux Sensorimoteurs, UMR 7060 CNRS, Université Paris  Descartes, Centre Universitaire des Saints-Pères, Paris, France. frederic.charbonnier@univ-paris5.fr

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  • Due to the prevalence of neuromuscular  disorders such as amyotrophic lateral sclerosis and spinal muscular atrophy in  modern societies, defining new and efficient strategies for the treatment of  these two neurodegenerative diseases has become a vital and still unfulfilled  urge. Several lines of experimental evidence have emphasized the benefits of  regular exercise training in mouse models for these affections in terms of life  span increase and improvement of both motor capacities and motoneuron survival.  Identifying molecules that could mimic the neuroprotective effects of exercise  represents a promising way to find novel therapies. Some of the effects of  exercise are caused by the overproduction of circulating neurotrophic factors,  such as IGF-I, whereas others may be due to modifications of the intrinsic  properties of the motoneurons within the spinal cord. The causal relationship  that links these potential effects of exercise training and the improvement of  motor capacity and life span expectancy is consequently  discussed.

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  • PMID:  17917110

 


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