• 来稿:陈琳   北京市虹天济神经科学研究院

  • Cell Mol Neurobiol. 2007 Mar;27(2):171-7.  

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  • Neuroprotective agents: is effective on  toxicity in glial cells?

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  • Dagci T, Yilmaz O, Taskiran D, Peker  G.

  • Ege University School of Medicine, Izmir, Turkey. tanerdagci@gmail.com

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  • 1. Glial cells are the most abundant  cell population in the central nervous system. The aim of this study was to  examine the effects of melatonin, 7-nitroindazole, and riluzole on glutamate  toxicity in primary glial cell culture. 2. Glutamate toxicity was induced by  addition of 100 microM glutamate to the cultures, and then 100 microM melatonin,  500 microM 7-nitroindazole, and 10 (M riluzole were administered in different  groups. Lactate Dehydrogenase activity and nitrite levels were determined at the  1st, 6th, and 24th h. 3. Melatonin, 7-nitroindazole, and riluzole decrease  Lactate Dehydrogenase activity at the 1st, 6th, and 24th h (at all hours,  p<0.05). Nitrite levels were decreased by melatonin and riluzole at the 1st,  6th, and 24th h. 4. In this study, we observed that melatonin, 7-nitroindazole,  and riluzole are effective as protective agents on glutamate toxicity in mixed  glial cells.

 

 

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