• 来稿:陈琳   北京市虹天济神经科学研究院

  • Stem Cells. 2007  Oct;25(10):2396-407

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  • Concise review: prospects of stem cell therapy for  temporal lobe epilepsy 

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  • Shetty  AK,  Hattiangady B.

  • Department of Surgery (Neurosurgery), Duke University Medical Center, Durham, North Carolina  27710, USA. Ashok.Shetty@duke.edu

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  • Certain regions of the adult brain have  the ability for partial self-repair after injury through production of new  neurons via activation of neural stem/progenitor cells (NSCs). Nonetheless,  there is no evidence yet for pervasive spontaneous replacement of dead neurons  by newly formed neurons leading to functional recovery in the injured brain.  Consequently, there is enormous interest for stimulating endogenous NSCs in the  brain to produce new neurons or for grafting of NSCs isolated and expanded from  different brain regions or embryonic stem cells into the injured brain. Temporal  lobe epilepsy (TLE), characterized by hyperexcitability in the hippocampus and  spontaneous seizures, is a possible clinical target for stem cell-based  therapies. This is because these approaches have the potential to curb  epileptogenesis and prevent chronic epilepsy development and learning and memory  dysfunction after hippocampal damage related to status epilepticus or head  injury. Grafting of NSCs may also be useful for restraining seizures during  chronic epilepsy. The aim of this review is to evaluate current knowledge and  outlook pertaining to stem cell-based therapies for TLE. The first section  discusses the behavior of endogenous hippocampal NSCs in human TLE and animal  models of TLE and evaluates the role of hippocampal neurogenesis in the  pathophysiology and treatment of TLE. The second segment considers the prospects  for preventing or suppressing seizures in TLE using exogenously applied stem  cells. The final part analyzes problems that remain to be resolved before  initiating clinical application of stem cell-based therapies for TLE. Disclosure  of potential conflicts of interest is found at the end of this  article.


6-羟多巴胺单侧帕金森病大鼠模型中染料木黄酮的神经保护作用
多发性硬化中的神经保护

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