• 来稿:陈琳   北京市虹天济神经科学研究院

  • Philos Trans R Soc Lond B Biol Sci. 2006  Sep 29;361(1473):1463-75.   

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  • Cell replacement therapy in neurological  disease

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  • Goldman SA, Windrem  MS.

  • Division of Cell and Gene Therapy, Department of Neurology,  University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 645,  Rochester, NY 14642, USA. steven_goldman@urmc.rochester.edu

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  • Diseases of the brain and spinal cord  represent especially daunting challenges for cell-based strategies of repair,  given the multiplicity of cell types within the adult central nervous system,  and the precision with which they must interact in both space and time.  Nonetheless, a number of diseases are especially appropriate for cell-based  therapy, in particular those in which single phenotypes are lost, and in which  the re-establishment of vectorially specific connections is not entirely  requisite for therapeutic benefit. We review here a set of potential therapeutic  indications that meet these criteria as potentially benefiting from the  transplantation of neural stem and progenitor cells. These include: (i)  transplantation of phenotypically restricted neuronal progenitor cells into  diseases of a single neuronal phenotype, such as Parkinson's disease; (ii)  implantation of mixed progenitor pools into diseases characterized by the loss  of a limited number of discrete phenotypes, such as spinal cord injury and the  motor neuronopathies; (iii) transplantation of glial and nominally  oligodendrocytic progenitor cells as a means of treating disorders of myelin;  and (iv) transplantation of neural stem cells as a means of treating lysosomal  storage disorders and other diseases of enzymatic deficiency. Among the diseases  potentially approachable by these strategies, the myelin disorders, including  the paediatric leucodystrophies as well as adult traumatic and inflammatory  demyelinations, may present the most compelling targets for cell-based  neurological therapy.


脊髓损伤修复:海潮前的涟漪,或我40年的研究是如何进行的
中枢神经系统中的神经元再生

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