• 来稿:陈琳   北京市虹天济神经科学研究院

  • Spinal Cord. 2006  Jul;44(7):406-13.

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  • Repair of spinal cord injury: ripples of  an incoming tide, or how I spent my first 40 years in  research

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  • Raisman  G.

  • Spinal Repair Unit, Institute of Neurology, University College London,  London, UK.

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  • Abstract of the inaugural lecture on  appointment to the Chair of Neural Regeneration at University College London January 2006. Record of personal  research.

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  • Electron microscopic observations led to  the concept that the adult brain is capable of forming new synapses after  injury, and the search for methods to repair brain and spinal cord injuries. It  is proposed that the failure of regeneration after central axotomy is due to  protective glial scarring leading to the loss of the aligned astrocytic pathways  needed for axon elongation. Taking advantage of the discovery that the adult  olfactory system is capable of continual renewal, cultured olfactory ensheathing  cells were transplanted into lesions of the spinal cord and spinal roots. The  transplants re-opened scarred glial pathways, allowed the regeneration of  severed nerve fibres, and the restoration of various functions, including paw  reaching, climbing, and supraspinal respiratory impulses to the phrenic  nerve.


神经保护与神经退行性疾病:从生物学到临床应用
神经学疾病中的细胞替代疗法

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脊髓损伤修复:海潮前的涟漪,或我40年的研究是如何进行的