• 来稿:陈琳   北京市虹天济神经科学研究院

  • Expert Opin Biol Ther. 2005  Mar;5(3):289-91.

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  • Cell therapies for neurological disease  — from bench to clinic to bench

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  • Harrower T, Barker  RA.

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  • The lack of any meaningful regeneration in the adult  central nervous system (CNS) subsequent to damage or degeneration stimulated the  concept of replacement of the deficient cells by transplantation. Thus, much  time and effort has been spent on investigating the potential of cell  replacement therapy for repair in a range of conditions of the CNS over the last  25 years. As promising proof of principle basic science results were slowly  converted to success in clinical transplantation trials in Parkinson's disease  (PD), the future seemed very encouraging for cell therapy. However, the recent  randomised, double-blind, placebo-controlled studies of fetal neural  transplantation in PD have produced more equivocal results, which has dampened  enthusiasm for this approach. However, whilst the translation of cell therapies  to the clinic is in limbo, the emergence of stem cells as a source of the  replacement tissue has revitalised the laboratory-based studies. This paper  attempts to reconcile these disparate views and put forward the authors' view on  the future of this form of biological therapy and its implications for related  therapies.

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优化可塑性:移植介导的脑修复中与环境和训练相关的因素
无瘢痕愈合:从胚胎机制到成人治疗干预策略

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神经疾病的细胞疗法:基础研究指导临床应用,临床应用升华基础研究