• 来稿:陈琳   北京市虹天济神经科学研究院

  • Neurotox Res.  2000;2(2-3):71-84.

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  • Neuroprotective and neurorestorative  strategies for neuronal injury

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  • Beal MF, Palomo T, Kostrzewa RM, Archer  T.

  • Department of Neurology and Neuroscience, Weill Medical  College of Cornell University, 525 East 68th Street, New York, NY 10021,  USA.

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  • Mechanisms of neuronal cell death in  apoptosis and necrosis are examined. Neurotoxic processes underlying cellular  destruction may involve N-methyl-D-aspartate (NMDA) receptor activation and/or  activation of neuronal nitric oxide synthase but the depletion of energy and  generation of free radicals appears to be critical. In Alzheimer's disease the  damaging effects of peroxynitrite and exposure to beta-amyloid peptide is  evident. Mitochondrial dysfunction is involved in several neurodegenerative  diseases including Parkinson's disease, amyotrophic lateral sclerosis,  Huntington's disease as well as Alzheimer's disease and in these disorders the  innovations offered by techniques ranging from transgenic mouse models of the  disorder to cell culture preparations are remarkable. Agents of neuroprotection  and neurorestoration possess either characteristics specific to particular  disorders or have a general applicability or both. The vast array of agents  available are for the most part the objectives of laboratory examinations but an  increasing selection of compounds are reaching the clinical necessities thereby  influencing current strategic notions to modify tactical contingencies. Among  the agents listed are included: inhibitors of the enzyme poly-ADP-ribose  polymerase, inhibition of apoptotic cell death, agents acting on mitochondrial  permeability transition, excitatory amino acid antagonists, applications of  neurotrophins, immunophilins, agents influencing heme oxygenase-1 expression and  iron sequestration in aging astroglia, improvements in mitochondrial energy  production or buffering, and finally dopaminemimetics with differential  affinities for dopamine receptors.

 


姜黄素的神经保护性作用
脊髓性肌萎缩模型小鼠的运动性神经保护:一种为确定新治疗策略的途径

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神经元损伤的神经保护作用与神经修复策略