• 来稿:陈琳   北京市虹天济神经科学研究院

    Phytother Res. 2008 Aug  11.

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  • Neuroprotective effect of genistein in 6-hydroxydopamine  Hemi-parkinsonian rat model

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  • Baluchnejadmojarad T, Roghani M, Nadoushan MR, Bagheri M.  
    Department of Physiology,  School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

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  • A large body of experimental evidence  supports a role for oxidative stress as a mediator of nerve cell death in  Parkinson's disease (PD). Phytoestrogens such as genistein have been reported to  prevent neuronal degeneration caused by increased oxidative burden, therefore,  this study examined whether genistein administration at a high dose would  attenuate behavioral and structural abnormalities in an experimental model of PD  in rat. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA,  12.5 microg/5 microL of saline-ascorbate)-lesioned rats were intraperitoneally  pretreated with a single and high dose of genistein (10 mg/kg) 1 h before  surgery. Apomorphine-induced rotations and the number of Nissl-stained neurons  in the substantia nigra pars compacta (SNC) were counted after 2 weeks.  Genistein administration could attenuate the rotational behavior in lesioned  rats and protect the neurons of SNC against 6-OHDA toxicity. Genistein  administration has a protective effect against 6-OHDA  toxicity.


 

 


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