• Neuroprotective actions of FK506 and cyclosporin A on  motor neuron survival following neonatal axotomy


  • Iwasaki Y, Ichikawa Y, Igarashi O, Iwamoto K, Kinoshitata  M, Ikeda K.


  • We show that nonimmunosuppressive analogues of the  immunosuppressive drugs FK506 and cyclosporin A (CsA) rescue axotomized neonatal  motor neuron death. Unilateral sciatic nerve was transected in neonatal rats.  Animals were then treated daily with different doses of FK506 and CsA for 14  days with intraperitoneal injection. Control rats received phosphate buffer  saline (PBS) in the same fashion. After treatment, the number of spinal motor  neurons was determined at L4 level. In comparison with vehicle, both FK506 (5.0  mg kg(-1)) and CsA (10.0 mg kg(-1)) rescued motor neuron death in a similar way.  These results indicate therapeutic relevance in the treatment of damaged motor  neuron disorders, such as motor neuropathy or amyotrophic lateral  sclerosis.